{"id":359,"date":"2025-02-24T18:50:49","date_gmt":"2025-02-24T09:50:49","guid":{"rendered":"https:\/\/saito-naika-cl.com\/blog\/?p=359"},"modified":"2025-10-06T16:13:41","modified_gmt":"2025-10-06T07:13:41","slug":"post-359","status":"publish","type":"post","link":"https:\/\/saito-naika-cl.com\/blog\/post-359\/","title":{"rendered":"\u809d\u786c\u5909\u306e\u65b0\u85ac\u60c5\u5831\u3084\u6700\u65b0\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u52d5\u5411"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"566\" height=\"377\" src=\"https:\/\/saito-naika-cl.com\/blog\/wp-content\/uploads\/2025\/02\/df7fb7b1772c96a6b08cac66fe356219.png\" alt=\"\" class=\"wp-image-360\" srcset=\"https:\/\/saito-naika-cl.com\/blog\/wp-content\/uploads\/2025\/02\/df7fb7b1772c96a6b08cac66fe356219.png 566w, https:\/\/saito-naika-cl.com\/blog\/wp-content\/uploads\/2025\/02\/df7fb7b1772c96a6b08cac66fe356219-400x266.png 400w\" sizes=\"auto, (max-width: 566px) 100vw, 566px\" \/><\/figure>\n<\/div>\n\n\n<p>\u809d\u786c\u5909\u306f\u3001\u809d\u81d3\u306e\u6162\u6027\u7684\u306a\u640d\u50b7\u306b\u3088\u3063\u3066\u7dda\u7dad\u5316\u304c\u9032\u884c\u3057\u3001\u809d\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u75be\u60a3\u3067\u3059\u3002\u7279\u306b\u3001B\u578b\u30fbC\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u304c\u4e3b\u306a\u539f\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u809d\u786c\u5909\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u809d\u79fb\u690d\u304c\u4e2d\u5fc3\u3067\u3059\u304c\u3001\u65b0\u85ac\u958b\u767a\u3084\u81e8\u5e8a\u8a66\u9a13\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u85ac\u7269\u7642\u6cd5\u306b\u3088\u308b\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u809d\u786c\u5909\u306e\u6700\u65b0\u306e\u65b0\u85ac\u60c5\u5831\u3068\u81e8\u5e8a\u8a66\u9a13\u306e\u52d5\u5411\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>1. Rezdiffra<\/strong><strong>\uff08\u30ec\u30ba\u30c7\u30a3\u30d5\u30e9\uff09\uff5cNASH\u6cbb\u7642\u85ac\u3068\u3057\u3066FDA\u521d\u627f\u8a8d<\/strong><\/p>\n\n\n\n<p>2024\u5e743\u670814\u65e5\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306f\u3001\u30de\u30c9\u30ea\u30ac\u30eb\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba\u793e\u306eRezdiffra\uff08\u4e00\u822c\u540d\uff1aresmetirom\uff09\u3092\u8fc5\u901f\u627f\u8a8d\u3002\u3053\u308c\u306f\u3001NASH\uff08\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u708e\uff09\u6cbb\u7642\u85ac\u3068\u3057\u3066\u521d\u306eFDA\u627f\u8a8d\u3068\u306a\u308b\u753b\u671f\u7684\u306a\u65b0\u85ac\u30022024\u5e744\u6708\u304b\u3089\u7c73\u56fd\u5e02\u5834\u3067\u306e\u8ca9\u58f2\u958b\u59cb\u4e88\u5b9a\u3002<\/p>\n\n\n\n<p>Rezdiffra\u306f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u03b2\uff08THR-\u03b2\uff09\u4f5c\u52d5\u85ac\u3067\u3042\u308a\u3001\u809d\u7d30\u80de\u306e\u8102\u80aa\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u3001\u8102\u80aa\u306e\u84c4\u7a4d\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\uff08MAESTRO-NASH\uff09\u3067\u306f\u300152\u9031\u9593\u306e\u6cbb\u7642\u5f8c\u3001\u88ab\u9a13\u8005\u306eNASH\u306e\u6d88\u5931\u7387\u304c\u5927\u5e45\u306b\u5411\u4e0a\u3057\u3001\u7dda\u7dad\u5316\u306e\u6539\u5584\u3082\u8a8d\u3081\u3089\u308c\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3001\u809d\u7dda\u7dad\u5316\u30b9\u30c6\u30fc\u30b8F2\uff5eF3\u306e\u60a3\u8005\u306e\u7d0425\uff5e30%\u3067\u6709\u610f\u306a\u6539\u5584\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u73fe\u5728\u3001\u65e5\u672c\u56fd\u5185\u3067\u306e\u627f\u8a8d\u7533\u8acb\u306b\u5411\u3051\u305f\u52d5\u304d\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>2. Efruxifermin<\/strong><strong>\uff08\u30a8\u30d5\u30eb\u30ad\u30b7\u30d5\u30a7\u30eb\u30df\u30f3\uff09\uff5c\u809d\u7dda\u7dad\u5316\u9006\u8ee2\u306e\u53ef\u80fd\u6027<\/strong><\/p>\n\n\n\n<p>2025\u5e741\u670827\u65e5\u3001Akero Therapeutics\u793e\u306f\u3001\u809d\u786c\u5909\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fEfruxifermin\uff08EFX\uff09\u306e\u81e8\u5e8a\u7b2c2b\u76f8\u8a66\u9a13\u3067\u3001\u809d\u7dda\u7dad\u5316\u3092\u9006\u8ee2\u3055\u305b\u308b\u52b9\u679c\u3092\u78ba\u8a8d\u3068\u767a\u8868\u3002\u6cbb\u7642\u7fa4\u3067\u306f39%\u306e\u60a3\u8005\u304c\u809d\u7dda\u7dad\u5316\u306e\u6539\u5584\u3092\u793a\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e15%\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306a\u6539\u5584\u304c\u898b\u3089\u308c\u305f\u300296\u9031\u9593\u306e\u8a66\u9a13\u30c7\u30fc\u30bf\u306b\u3088\u308a\u3001\u6301\u7d9a\u7684\u306a\u809d\u6a5f\u80fd\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u308b\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002<\/p>\n\n\n\n<p>Efruxifermin\u306fFGF21\u30a2\u30ca\u30ed\u30b0\uff08\u7dda\u7dad\u82bd\u7d30\u80de\u6210\u9577\u56e0\u5b5021\uff09\u3067\u3042\u308a\u3001\u8102\u80aa\u4ee3\u8b1d\u3092\u4fc3\u9032\u3057\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3067\u809d\u786c\u5909\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u3002\u540c\u69d8\u306e\u4f5c\u7528\u3092\u6301\u3064\u4ed6\u306e\u85ac\u5264\u3068\u6bd4\u3079\u3001\u3088\u308a\u5f37\u529b\u306a\u7dda\u7dad\u5316\u6539\u5584\u52b9\u679c\u304c\u793a\u3055\u308c\u305f\u3002\u73fe\u5728\u3001\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u6e96\u5099\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u6210\u529f\u3059\u308c\u3070\u809d\u786c\u5909\u6cbb\u7642\u306e\u65b0\u305f\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>3. Semaglutide<\/strong><strong>\uff08\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff09\uff5cMASH\u60a3\u8005\u306e\u809d\u7dda\u7dad\u5316\u6539\u5584<\/strong><\/p>\n\n\n\n<p>Novo Nordisk\u793e\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u300cSemaglutide\uff08GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff09\u300d\u304c\u3001MASH\uff08\u4ee3\u8b1d\u6027\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u708e\uff09\u60a3\u8005\u306e\u809d\u7dda\u7dad\u5316\u6539\u5584\u306b\u52b9\u679c\u3092\u793a\u3057\u305f\u30022024\u5e7411\u6708\u306b\u767a\u8868\u3055\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf\u3067\u306f\u300172\u9031\u9593\u306e\u6295\u4e0e\u306737%\u306e\u60a3\u8005\u306b\u809d\u7dda\u7dad\u5316\u306e\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n\n\n\n<p>Semaglutide\u306f\u3001\u4f53\u91cd\u6e1b\u5c11\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u6539\u5584\u306b\u52b9\u679c\u3092\u6301\u3064\u85ac\u5264\u3067\u3001\u7cd6\u5c3f\u75c5\u3084\u80a5\u6e80\u75c7\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002MASH\u60a3\u8005\u3067\u306f\u3001\u809d\u8102\u80aa\u306e\u6e1b\u5c11\u304c\u7dda\u7dad\u5316\u6539\u5584\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u809d\u7dda\u7dad\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>4. <\/strong><strong>\u65e5\u672c\u306b\u304a\u3051\u308bNASH\u30fb\u809d\u786c\u5909\u6cbb\u7642\u85ac\u306e\u958b\u767a\u72b6\u6cc1<\/strong><\/p>\n\n\n\n<p>\u65e5\u672c\u56fd\u5185\u3067\u306f\u3001NASH\u304a\u3088\u3073\u809d\u786c\u5909\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u884c\u4e2d\u3002\u6d77\u5916\u4f01\u696d\u3068\u56fd\u5185\u88fd\u85ac\u4f01\u696d\u304c\u5171\u540c\u3067\u81e8\u5e8a\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u3001\u65e5\u672c\u5e02\u5834\u3078\u306e\u9069\u5fdc\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u306eNASH\u60a3\u8005\u6570\u306f\u7d04200\u4e07\uff5e300\u4e07\u4eba\u3068\u63a8\u5b9a\u3055\u308c\u3001\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u304c\u6025\u52d9\u3002\u56fd\u5185\u5927\u624b\u88fd\u85ac\u4f1a\u793e\u304c\u65b0\u85ac\u958b\u767a\u306b\u53c2\u753b\u3057\u3001\u6d77\u5916\u4f01\u696d\u3068\u5171\u540c\u3067\u81e8\u5e8a\u8a66\u9a13\u3092\u63a8\u9032\u30022024\u5e74\u4ee5\u964d\u3001\u65e5\u672c\u3067\u306e\u6cbb\u9a13\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u539a\u751f\u52b4\u50cd\u7701\u3078\u306e\u627f\u8a8d\u7533\u8acb\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/p>\n\n\n\n<p>\u809d\u786c\u5909\u6cbb\u7642\u306f\u3001\u5f93\u6765\u306e\u5bfe\u75c7\u7642\u6cd5\u304b\u3089\u6839\u672c\u7684\u306a\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078\u3068\u5927\u304d\u304f\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u518d\u751f\u533b\u7642\u3001\u6297\u7dda\u7dad\u5316\u85ac\u3001\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306a\u3069\u3001\u591a\u69d8\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u6700\u65b0\u306e\u7814\u7a76\u3084\u81e8\u5e8a\u8a66\u9a13\u306e\u9032\u5c55\u3092\u6ce8\u8996\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-pale-cyan-blue-background-color has-background has-fixed-layout\"><tbody><tr><td>\u5f53\u9662\u3067\u306f2024\u5e74\u304b\u3089\u3001\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u809d\u81d3\u306e\u518d\u751f\u533b\u7642\u3082\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002<br>\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3082\u3054\u3056\u3044\u307e\u3059\u306e\u3067\u3001\u305c\u3072\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<br><br><a href=\"https:\/\/saito-cl-liver-regeneration.com\/\" target=\"_blank\" rel=\"noopener\" title=\"\">\u3055\u3044\u3068\u3046\u5185\u79d1\u30af\u30ea\u30cb\u30c3\u30af \u809d\u81d3\u518d\u751f\u533b\u7642\u30b5\u30a4\u30c8<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u809d\u786c\u5909\u306f\u3001\u809d\u81d3\u306e\u6162\u6027\u7684\u306a\u640d\u50b7\u306b\u3088\u3063\u3066\u7dda\u7dad\u5316\u304c\u9032\u884c\u3057\u3001\u809d\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u75be\u60a3\u3067\u3059\u3002\u7279\u306b\u3001B\u578b\u30fbC\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u3001\u30a2\u30eb\u30b3\u30fc\u30eb&#8230;<\/p>\n","protected":false},"author":2,"featured_media":360,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"class_list":["post-359","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/posts\/359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/comments?post=359"}],"version-history":[{"count":3,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/posts\/359\/revisions"}],"predecessor-version":[{"id":462,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/posts\/359\/revisions\/462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/media\/360"}],"wp:attachment":[{"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/media?parent=359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saito-naika-cl.com\/blog\/wp-json\/wp\/v2\/categories?post=359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}